COVID-19 pandemic brought on by SARS-CoV-2 has already resulted big setback to mankind in phrases of tens of millions of deaths whereas the unavailability of acceptable therapeutic technique has made the situation far more extreme. Toll-like receptors (TLRs) are the essential mediators and regulators of […]
Month: March 2021
Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists
Toll-like receptors (TLRs) play key function in innate immune response to Damage Associated Molecular Patterns (DAMPs) and Pathogen Associated Molecular Patterns (PAMPs). DAMP/PAMP-mediated activation of TLRs triggers NFκB signaling leading to pro-inflammatory cytokine launch. Using TLR2-Pam2CSK4 agonist co-crystal construction info, we designed and synthesized a […]