Retinoids are used in the remedy of inflammatory pores and skin ailments and malignancies, however research characterizing the in vivo actions of those medicine in people are missing. Isotretinoin is a pro-drug for all-trans retinoic acid, which might induce long-term remissions of acne; nonetheless, its full mechanism of motion is unknown. We hypothesized that isotretinoin induces remission of acne by normalizing the innate immune response to the commensal bacterium Propionibacterium acnes.
Compared with regular topics, peripheral blood monocytes from acne sufferers expressed considerably increased ranges of Toll-like receptor 2 (TLR-2) and exhibited considerably higher induction of TLR-2 expression following P. acnes stimulation. Treatment of sufferers with isotretinoin considerably decreased monocyte TLR-2 expression and subsequent inflammatory cytokine response to P. acnes after 1 week of therapy.
This impact was sustained 6 months following cessation of therapy, indicating that TLR-2 modulation could also be concerned in the sturdy therapeutic response to isotretinoin. This research demonstrates that isotretinoin exerts immunomodulatory results in sufferers and sheds mild on a possible mechanism for its long-term results on acne. The modulation of TLR-2 expression on monocytes has vital implications in different inflammatory issues characterised by TLR-2 dysregulation.
Pellino <em>2</em> is crucial for Toll-like receptor/interleukin-1 receptor (<em>TLR</em>/IL-1R)-mediated post-transcriptional management.
Interleukin 1 receptor-associated kinase 1(IRAK1), a key molecule in TLR/IL-1R-mediated signaling, is phosphorylated, ubiquitinated, and degraded upon ligand stimulation. We and others have just lately recognized Pellino proteins as novel RING E3 ubiquitin ligases concerned in IRAK1 polyubiquitination and degradation. However, it stays unclear how every Pellino member distinctly regulates TLR/IL-1R signaling by modulating IRAK1 ubiquitination.
In this research we examined the function of Pellino 2 in IL-1- and LPS-mediated signaling and gene expression by flattening Pellino 2 in human 293-IL-1R cells and first bone marrow macrophages. Pellino 2 (however not Pellino 1) knockdown abolished IL-1- and LPS-induced Lys-63-linked IRAK1 ubiquitination with lowered Lys-48-linked IRAK1 ubiquitination. Furthermore, Pellino 2 is required for TAK1-dependent NFκB activation.
However, due to the retained TAK1-independent NFκB activation, the degrees of IL-1- and LPS-induced NFκB activation weren’t considerably affected in Pellino 2 knockdown 293-IL-1R cells and first macrophages, respectively. On the opposite hand, Pellino 2 knockdown lowered the IL-1- and LPS-induced inflammatory gene expression at late time factors, which was accompanied by elevated decay charges of the mRNAs of the inflammatory genes.
Importantly, IL-1- and LPS-mediated JNK and ERK activation have been considerably attenuated in Pellino 2 knock-down cells, implicating MAPK activation in TLR/IL-1R-induced mRNA stabilization. Taken collectively, this research demonstrated that Pellino 2 performs a crucial function for TLR/IL-1R-mediated post-transcriptional management.
Extracts of Larix Leptolepis successfully augments the era of tumor antigen-specific cytotoxic T lymphocytes by way of activation of dendritic cells in <em>TLR</em>-<em>2</em> and <em>TLR</em>-4-dependent method.
Type-1 immunity performs a vital function in host protection in opposition to varied tumors and infectious ailments. Here, we first demonstrated that extract of Larix Leptolepis (ELL), one of the vital standard timbers at Hokkaido space in Japan, strongly activated Type-1 immunity. ELL induced manufacturing of Type-1 cytokines similar to IL-12 and TNF-α from bone marrow-derived dendritic cells (BMDCs) in TLR2- and TLR4-dependent method and remarkably up-regulated the expression of MHC and co-stimulatory molecules.
In addition, antigen-specific CTLs have been considerably augmented by the mixed administration of ELL, antigen and BMDCs. Finally, we revealed that mixture therapy utilizing ELL, antigen and BMDCs considerably inhibited the expansion of established tumor in mouse mannequin. Thus, these findings instructed that ELL can be a novel adjuvant for inducing an activation of Type-1-dependent immunity together with activation of BMDCs and induction of tumor-specific CTLs, which is relevant to the therapy of most cancers and infectious ailments.
Ubiquitin-like protein MNSFβ regulates <em>TLR</em>-<em>2</em>-mediated sign transduction.
Post-translational modification by monoclonal nonspecific suppressor issue β (MNSFβ) has been concerned in the regulation of a wide range of mobile processes. Previous research have demonstrated that MNSFβ covalently binds to the intracellular pro-apoptotic protein Bcl-G and regulates TLR-4-mediated sign transduction. Recently, we discovered that MNSFβ additionally covalently conjugates to endophilin II, a member of the endophilin A household, and inhibits the sign pathway upstream of IKK activation, however not downstream of TLR-2 signaling. In this research, we additional examined the mechanism of motion of MNSFβ in TLR-2-mediated sign transduction in macrophage-like cell line Uncooked264.7 cells.
Although MNSFβ siRNA enhanced Pam(3)CDK(4) (TLR-2-specific ligand)-stimulated TNFα manufacturing, Bcl-G siRNA didn’t have an effect on. MNSFβ cDNA inhibited the Pam(3)CDK(4)-stimulated TNFα manufacturing. High-molecular weight (130 kDa) MNSFβ-adduct was induced in Pam(3)CDK(4)-stimulated Uncooked264.7 cells. This MNSFβ-adduct was not induced by LPS, indicative of the specificity of TLR-2-mediated sign transduction. Similar observations have been seen in BALB/c peritoneal macrophages. Interestingly, 40-kDa MNSFβ-adduct was tyrosine phosphorylated by Pam(3)CDK(4) stimulation. Collectively, novel MNSFβ-adducts could regulate TLR-2 signaling pathway in macrophages.
Constitutive MHC class I molecules negatively regulate <em>TLR</em>-triggered inflammatory responses by way of the Fps-SHP-<em>2</em> pathway.
The molecular mechanisms that fine-tune Toll-like receptor (TLR)-triggered innate inflammatory responses stay to be totally elucidated. Major histocompatibility advanced (MHC) molecules can mediate reverse signaling and have nonclassical capabilities. Here we discovered that constitutively expressed membrane MHC class I molecules attenuated TLR-triggered innate inflammatory responses by way of reverse signaling, which protected mice from sepsis.
 Mouse Anti-Human IgM - Alexa Fluor 350 |
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| DL87132A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 Mouse Anti-Human IgA - Alexa Fluor 350 |
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| E38A3034 | EnoGene | 100μL | EUR 125 |
Mouse Anti-Human IgM - Alexa Fluor 350 |
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| E38A3038 | EnoGene | 100μL | EUR 125 |
Mouse Anti-Human IgA - Alexa Fluor 350 |
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| YLF0480-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgA - Alexa Fluor 350 |
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| YLF0480-1ml | Shanghai YL Biotech | 1 ml | EUR 300 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgA - Alexa Fluor 350 |
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| YLF0480-500ul | Shanghai YL Biotech | 500 ul | EUR 210 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgM - Alexa Fluor 350 |
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| YLF0205-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
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Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgM - Alexa Fluor 350 |
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| YLF0205-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
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Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgM - Alexa Fluor 350 |
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| YLF0205-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
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Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 Rabbit Anti-Human IgM - Alexa Fluor 350 |
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| DL87121A-100ul | DL Develop | 100 ul | EUR 190 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Human IgM - Alexa Fluor 350 |
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| DL87121A-500ul | DL Develop | 500 ul | EUR 280 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Human IgM - Alexa Fluor 350 |
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| E38A3025 | EnoGene | 100μL | EUR 125 |
Rabbit Anti-Human IgM - Alexa Fluor 350 |
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| YLF0477-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Human IgM - Alexa Fluor 350 |
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| YLF0477-1ml | Shanghai YL Biotech | 1 ml | EUR 300 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Human IgM - Alexa Fluor 350 |
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| YLF0477-500ul | Shanghai YL Biotech | 500 ul | EUR 210 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 Goat Anti-Human IgG Fc - Alexa Fluor 350 |
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| DL87100A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG Fc - Alexa Fluor 350 |
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| DL87100A-500ul | DL Develop | 500 ul | EUR 350 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG Fc - Alexa Fluor 350 |
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| E38A3004 | EnoGene | 100μL | EUR 125 |
Goat Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0183-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0183-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0183-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 Goat Anti-Human IgG Fab - Alexa Fluor 350 |
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| DL87099A-100ul | DL Develop | 100 ul | EUR 190 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG Fab - Alexa Fluor 350 |
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| DL87099A-500ul | DL Develop | 500 ul | EUR 280 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 Mouse Anti-Human IgG Fc - Alexa Fluor 350 |
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| DL87131A-100ul | DL Develop | 100 ul | EUR 190 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgG Fc - Alexa Fluor 350 |
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| DL87131A-500ul | DL Develop | 500 ul | EUR 280 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgG Fc - Alexa Fluor 350 |
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| E38A3036 | EnoGene | 100μL | EUR 125 |
Goat Anti-Human IgG Fab - Alexa Fluor 350 |
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| YLF0474-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG Fab - Alexa Fluor 350 |
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| YLF0474-1ml | Shanghai YL Biotech | 1 ml | EUR 300 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG Fab - Alexa Fluor 350 |
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| YLF0474-500ul | Shanghai YL Biotech | 500 ul | EUR 210 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0482-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
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Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0482-1ml | Shanghai YL Biotech | 1 ml | EUR 300 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0482-500ul | Shanghai YL Biotech | 500 ul | EUR 210 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 Rabbit Anti-Human IgG Fc - Alexa Fluor 350 |
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| DL87118A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Human IgG Fc - Alexa Fluor 350 |
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| DL87118A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 Mouse Anti-Human IgG Fab - Alexa Fluor 350 |
|||
| DL87130A-100ul | DL Develop | 100 ul | EUR 190 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Human IgG Fab - Alexa Fluor 350 |
|||
| DL87130A-500ul | DL Develop | 500 ul | EUR 280 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Human IgG Fc - Alexa Fluor 350 |
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| E38A3022 | EnoGene | 100μL | EUR 125 |
Mouse Anti-Human IgG Fab - Alexa Fluor 350 |
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| E38A3035 | EnoGene | 100μL | EUR 125 |
Mouse Anti-Human IgG Fab - Alexa Fluor 350 |
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| YLF0481-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Human IgG Fab - Alexa Fluor 350 |
|||
| YLF0481-1ml | Shanghai YL Biotech | 1 ml | EUR 300 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Human IgG Fab - Alexa Fluor 350 |
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| YLF0481-500ul | Shanghai YL Biotech | 500 ul | EUR 210 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0198-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Human IgG Fc - Alexa Fluor 350 |
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| YLF0198-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Human IgG Fc - Alexa Fluor 350 |
|||
| YLF0198-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Goat Anti-Pig IgG (H&L) - Alexa Fluor 350 |
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| DL87106A-100ul | DL Develop | 100 ul | EUR 155 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| DL87106A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| E38A3010 | EnoGene | 100μL | EUR 125 |
Goat Anti-Pig IgG (H&L) - Alexa Fluor 350 |
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| YLF0187-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0187-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0187-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Mouse Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| DL87135A-100ul | DL Develop | 100 ul | EUR 190 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| DL87135A-500ul | DL Develop | 500 ul | EUR 280 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| E38A3041 | EnoGene | 100μL | EUR 125 |
Mouse Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0485-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0485-1ml | Shanghai YL Biotech | 1 ml | EUR 300 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0485-500ul | Shanghai YL Biotech | 500 ul | EUR 210 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Goat Anti-Human IgG (H&L) - Alexa Fluor 350 |
|||
| DL87098A-100ul | DL Develop | 100 ul | EUR 140 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Human IgG (H&L) - Alexa Fluor 350 |
|||
| DL87098A-500ul | DL Develop | 500 ul | EUR 330 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Goat Anti-Mouse IgG (H&L) - Alexa Fluor 350 |
|||
| DL87104A-100ul | DL Develop | 100 ul | EUR 140 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Mouse IgG (H&L) - Alexa Fluor 350 |
|||
| DL87104A-500ul | DL Develop | 500 ul | EUR 330 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Rabbit Anti-Cat IgG (H&L) - Alexa Fluor 350 |
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| DL87109A-100ul | DL Develop | 100 ul | EUR 155 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Cat IgG (H&L) - Alexa Fluor 350 |
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| DL87109A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Rabbit Anti-Dog IgG (H&L) - Alexa Fluor 350 |
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| DL87111A-100ul | DL Develop | 100 ul | EUR 155 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Dog IgG (H&L) - Alexa Fluor 350 |
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| DL87111A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Rabbit Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| DL87124A-100ul | DL Develop | 100 ul | EUR 155 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| DL87124A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Rabbit Anti-Rat IgG (H&L) - Alexa Fluor 350 |
|||
| DL87125A-100ul | DL Develop | 100 ul | EUR 155 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Rat IgG (H&L) - Alexa Fluor 350 |
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| DL87125A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Mouse Anti-Duck IgY (H&L) - Alexa Fluor 350 |
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| DL87128A-100ul | DL Develop | 100 ul | EUR 190 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Duck IgY (H&L) - Alexa Fluor 350 |
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| DL87128A-500ul | DL Develop | 500 ul | EUR 280 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Human IgG (H&L) - Alexa Fluor 350 |
|||
| E38A3002 | EnoGene | 100μL | EUR 125 |
Rabbit Anti-Cat IgG (H&L) - Alexa Fluor 350 |
|||
| E38A3013 | EnoGene | 100μL | EUR 125 |
Rabbit Anti-Dog IgG (H&L) - Alexa Fluor 350 |
|||
| E38A3015 | EnoGene | 100μL | EUR 125 |
Rabbit Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| E38A3028 | EnoGene | 100μL | EUR 125 |
Rabbit Anti-Rat IgG (H&L) - Alexa Fluor 350 |
|||
| E38A3029 | EnoGene | 100μL | EUR 125 |
Mouse Anti-Duck IgY (H&L) - Alexa Fluor 350 |
|||
| YLF0479-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Duck IgY (H&L) - Alexa Fluor 350 |
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| YLF0479-1ml | Shanghai YL Biotech | 1 ml | EUR 300 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Mouse Anti-Duck IgY (H&L) - Alexa Fluor 350 |
|||
| YLF0479-500ul | Shanghai YL Biotech | 500 ul | EUR 210 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Human IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0091-100ul | Shanghai YL Biotech | 100 ul | EUR 100 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG (H&L) - Alexa Fluor 350 |
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| YLF0091-1ml | Shanghai YL Biotech | 1 ml | EUR 490 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0091-500ul | Shanghai YL Biotech | 500 ul | EUR 300 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Mouse IgG (H&L) - Alexa Fluor 350 |
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| YLF0092-100ul | Shanghai YL Biotech | 100 ul | EUR 100 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Mouse IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0092-1ml | Shanghai YL Biotech | 1 ml | EUR 490 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Mouse IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0092-500ul | Shanghai YL Biotech | 500 ul | EUR 300 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Cat IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0189-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Cat IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0189-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Cat IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0189-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Dog IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0191-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Dog IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0191-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Dog IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0191-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0202-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0202-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Pig IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0202-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Rat IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0203-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Rat IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0203-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Rabbit Anti-Rat IgG (H&L) - Alexa Fluor 350 |
|||
| YLF0203-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 350 |
|||
| DL87107A-100ul | DL Develop | 100 ul | EUR 140 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 350 |
|||
| DL87107A-500ul | DL Develop | 500 ul | EUR 330 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
|||
 - Alexa Fluor 350) Rabbit Anti-Duck IgY (H&L) - Alexa Fluor 350 |
|||
| DL87113A-100ul | DL Develop | 100 ul | EUR 155 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Duck IgY (H&L) - Alexa Fluor 350 |
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| DL87113A-500ul | DL Develop | 500 ul | EUR 350 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Rabbit Anti-Goat IgG (H&L) - Alexa Fluor 350 |
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| DL87114A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Goat IgG (H&L) - Alexa Fluor 350 |
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| DL87114A-500ul | DL Develop | 500 ul | EUR 350 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 350 |
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| E38A3011 | EnoGene | 100μL | EUR 125 |
Rabbit Anti-Goat IgG (H&L) - Alexa Fluor 350 |
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| E38A3018 | EnoGene | 100μL | EUR 125 |
Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 350 |
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| YLF0093-100ul | Shanghai YL Biotech | 100 ul | EUR 100 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 350 |
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| YLF0093-1ml | Shanghai YL Biotech | 1 ml | EUR 490 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 350 |
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| YLF0093-500ul | Shanghai YL Biotech | 500 ul | EUR 300 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Duck IgY (H&L) - Alexa Fluor 350 |
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| YLF0193-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Duck IgY (H&L) - Alexa Fluor 350 |
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| YLF0193-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Duck IgY (H&L) - Alexa Fluor 350 |
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| YLF0193-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Goat IgG (H&L) - Alexa Fluor 350 |
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| YLF0194-100ul | Shanghai YL Biotech | 100 ul | EUR 130 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Goat IgG (H&L) - Alexa Fluor 350 |
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| YLF0194-1ml | Shanghai YL Biotech | 1 ml | EUR 480 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Goat IgG (H&L) - Alexa Fluor 350 |
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| YLF0194-500ul | Shanghai YL Biotech | 500 ul | EUR 290 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Goat Anti-Chicken IgY (H&L) - Alexa Fluor 350 |
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| DL87097A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Chicken IgY (H&L) - Alexa Fluor 350 |
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| DL87097A-500ul | DL Develop | 500 ul | EUR 350 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 Goat Anti-Human IgG+IgM+IgA - Alexa Fluor 350 |
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| DL87102A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Goat Anti-Human IgG+IgM+IgA - Alexa Fluor 350 |
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| DL87102A-500ul | DL Develop | 500 ul | EUR 350 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Rabbit Anti-Horse IgG (H&L) - Alexa Fluor 350 |
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| DL87116A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Horse IgG (H&L) - Alexa Fluor 350 |
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| DL87116A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Rabbit Anti-Human IgG (H&L) - Alexa Fluor 350 |
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| DL87117A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Human IgG (H&L) - Alexa Fluor 350 |
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| DL87117A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Rabbit Anti-Mouse IgG (H&L) - Alexa Fluor 350 |
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| DL87123A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Mouse IgG (H&L) - Alexa Fluor 350 |
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| DL87123A-500ul | DL Develop | 500 ul | EUR 350 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Rabbit Anti-Sheep IgG (H&L) - Alexa Fluor 350 |
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| DL87126A-100ul | DL Develop | 100 ul | EUR 155 |
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Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Rabbit Anti-Sheep IgG (H&L) - Alexa Fluor 350 |
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| DL87126A-500ul | DL Develop | 500 ul | EUR 350 |
|
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads. |
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 - Alexa Fluor 350) Mouse Anti-Monkey IgG (H&L) - Alexa Fluor 350 |
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| DL87133A-100ul | DL Develop | 100 ul | EUR 190 |
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Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Monkey IgG (H&L) - Alexa Fluor 350 |
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| DL87133A-500ul | DL Develop | 500 ul | EUR 280 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Monkey IgG (H&L) - Alexa Fluor 350 |
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| DL87134A-100ul | DL Develop | 100 ul | EUR 190 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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Mouse Anti-Monkey IgG (H&L) - Alexa Fluor 350 |
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| DL87134A-500ul | DL Develop | 500 ul | EUR 280 |
|
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads. |
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The intracellular area of MHC class I molecules was phosphorylated by the kinase Src after TLR activation, then the tyrosine kinase Fps was recruited by way of its Src homology 2 area to phosphorylated MHC class I molecules. This led to enhanced Fps exercise and recruitment of the phosphatase SHP-2, which interfered with TLR signaling mediated by the signaling molecule TRAF6. Thus, constitutive MHC class I molecules interact in crosstalk with TLR signaling by way of the Fps-SHP-2 pathway and management TLR-triggered innate inflammatory responses.
